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Figure 2 | Retrovirology

Figure 2

From: Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis

Figure 2

ABX464 inhibits different HIV-1 clades, resistant viruses and did not select for resistance. a Different HIV-1 strains (clade B, clade C and recombinants clades) were used to infect PBMCs from three different donors in the absence or presence of 5 μM of ABX464. Supernatant was harvested 6 days pi and viral capsid protein p24 antigen was quantitated using standard ELISA protocol. b RT activity (cpm) measured in human PBMCs infected with different resistant mutants of NL4.3 strain (K103N, K65R and M184V) and treated with ABX464 or 3TC. c Resistance to ABX464 was tested on human PBMCs and compared to current therapies (see Methods). There were no resistance-inducing mutations detected after treatment with ABX464 for at least 24 weeks.

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Retrovirology

ISSN: 1742-4690

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