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Table 3 Above-background cytokine responses to αGalCer at 5 days post-stimulation

From: Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment

Analyte HIV-negative (n = 14) HIV+ ART naïve (n = 8) HIV+ ART experienced (n = 14) p value ** Post-test differences ***
IFNγ N Detectible 13 7 8 0.057  
  Concentration* 345.9 (76.74, 2115) 34.97 (4.83, 142.7) 2.275, (0.0, 124.8) 0.003 HIV-N vs HIV+ ART
IL-4 N Detectible 7 3 2 0.129  
  Concentration* 3.06 (0.0, 22.02) 0.0 (0.0, 6.69) 0.0 (0.0, 0.18) 0.095  
IL-10 N Detectible 4 2 6 0.618  
  Concentration* 0.0 (0.0, 5.82) 0.0 (0.0, 4.25) 0.0 (0.0, 13.8) 0.683  
IL-13 N Detectible 11 5 6 0.152  
  Concentration* 199.1 (19.23, 477.0) 8.26 (0.11, 77.2) 0.0 (0.0, 25.45) 0.014 HIV-N vs HIV+ ART
IP-10 N Detectible 11 6 5 0.005  
  Concentration* 1586 (836.8, 6168) 329.3 (24.5, 5351) 0.0 (0.0, 409.6) 0.001 HIV-N vs HIV+ ART
MIP-1α N Detectible 6 4 4 0.409  
  Concentration* 0.0 (0.0, 198.4) 37.2 (0.0, 158.5) 0.0 (0.0, 75.6) 0.453  
MIP-1β N Detectible 8 4 4 0.368  
  Concentration* 78.16 (0.0, 370.2) 35.06 (0.0, 165.1) 0.0 (0.0, 104.6) 0.253  
TNFα N Detectible 10 7 6 0.084  
  Concentration* 52.34 (0.0, 317.1) 20.2 (4.74, 115.1) 0.065 (0.0, 140.2) 0.370  
  1. *Data are presented as median (IQR) in pg/mL.
  2. **p values obtained from Chi squared tests for N detectible data, Kruskal-Wallis tests for concentration comparisons.
  3. ***Dunn’s post-test comparisons with p < 0.05 are indicated for each significant Kruskal-Wallis result Statistical tests with p ≤ 0.1 (trend) are indicated in bold.