Skip to main content

Table 3 Above-background cytokine responses to αGalCer at 5 days post-stimulation

From: Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment

Analyte

HIV-negative (n = 14)

HIV+ ART naïve (n = 8)

HIV+ ART experienced (n = 14)

p value **

Post-test differences ***

IFNγ

N Detectible

13

7

8

0.057

 
 

Concentration*

345.9 (76.74, 2115)

34.97 (4.83, 142.7)

2.275, (0.0, 124.8)

0.003

HIV-N vs HIV+ ART

IL-4

N Detectible

7

3

2

0.129

 
 

Concentration*

3.06 (0.0, 22.02)

0.0 (0.0, 6.69)

0.0 (0.0, 0.18)

0.095

 

IL-10

N Detectible

4

2

6

0.618

 
 

Concentration*

0.0 (0.0, 5.82)

0.0 (0.0, 4.25)

0.0 (0.0, 13.8)

0.683

 

IL-13

N Detectible

11

5

6

0.152

 
 

Concentration*

199.1 (19.23, 477.0)

8.26 (0.11, 77.2)

0.0 (0.0, 25.45)

0.014

HIV-N vs HIV+ ART

IP-10

N Detectible

11

6

5

0.005

 
 

Concentration*

1586 (836.8, 6168)

329.3 (24.5, 5351)

0.0 (0.0, 409.6)

0.001

HIV-N vs HIV+ ART

MIP-1α

N Detectible

6

4

4

0.409

 
 

Concentration*

0.0 (0.0, 198.4)

37.2 (0.0, 158.5)

0.0 (0.0, 75.6)

0.453

 

MIP-1β

N Detectible

8

4

4

0.368

 
 

Concentration*

78.16 (0.0, 370.2)

35.06 (0.0, 165.1)

0.0 (0.0, 104.6)

0.253

 

TNFα

N Detectible

10

7

6

0.084

 
 

Concentration*

52.34 (0.0, 317.1)

20.2 (4.74, 115.1)

0.065 (0.0, 140.2)

0.370

 
  1. *Data are presented as median (IQR) in pg/mL.
  2. **p values obtained from Chi squared tests for N detectible data, Kruskal-Wallis tests for concentration comparisons.
  3. ***Dunn’s post-test comparisons with p < 0.05 are indicated for each significant Kruskal-Wallis result Statistical tests with p ≤ 0.1 (trend) are indicated in bold.
Back to article page

Retrovirology

ISSN: 1742-4690

Contact us