Table 1 Physical characteristics an anti-HIV activity of griffithsin tandemers
From: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus
Name | Number of domains | Linker | Molecular Weight (kDa) | Anti-HIV EC 50 1 (pM) | Terminal binding surface distance (Å) |
|---|---|---|---|---|---|
GRFT | 2 | none | 25.6 | 13.8 ± 0.3 | 50 |
mGRFT (1GS-S [30]) | 1 | none | 12.8 | 119,300 ± 19,300 | n.a. |
2mGRFT | 2 | Gly-Thr-Gly | 25.8 | 2.7 ± 2.7 | 70 |
2mGRFT3 | 2 | (Gly-Thr-Gly) 3 | 26.2 | 2.6 ± 5.3 | 90 |
3mGRFT | 3 | Gly-Thr-Gly | 38.8 | 1.0 ± 2.9 | 90 |
4mGRFT | 4 | Gly-Thr-Gly | 51.8 | 1.2 ± 0.3 | 100 |