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Table 1 Physical characteristics an anti-HIV activity of griffithsin tandemers

From: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

Name Number of domains Linker Molecular Weight (kDa) Anti-HIV EC 50 1 (pM) Terminal binding surface distance (Å)
GRFT 2 none 25.6 13.8 ± 0.3 50
mGRFT (1GS-S [30]) 1 none 12.8 119,300 ± 19,300 n.a.
2mGRFT 2 Gly-Thr-Gly 25.8 2.7 ± 2.7 70
2mGRFT3 2 (Gly-Thr-Gly) 3 26.2 2.6 ± 5.3 90
3mGRFT 3 Gly-Thr-Gly 38.8 1.0 ± 2.9 90
4mGRFT 4 Gly-Thr-Gly 51.8 1.2 ± 0.3 100
  1. 1Effective concentration at which 50% of CEM-SS cells are protected from the cytopathic effects of HIV-1RF infection.