Figure 12

SPR sensorgrams showing the binding and dissociation of CBAs to gp120 and gp41. For each compound, a two-fold dilution series was tested and shown in different colors. The 1:1 binding model was used to fit the curves (shown in black). A. HHA vs gp120, highest concentration: 10 nM. B. HHA vs gp41, highest concentration: 10 nM. C. UDA vs gp120, highest concentration: 80 nM. D. UDA vs gp41, highest concentration: 80 nM. E. AH vs gp120, highest concentration: 80 nM. F. AH vs gp41, highest concentration: 80 nM. G. 2G12 vs gp120, highest concentration: 500 nM. H. 2G12 vs gp41, highest concentration: 500 nM. The results represent one of at least 2 independent experiments.