Figure 5
From: Characterization of HIV-1 envelopes in acutely and chronically infected injection drug users
Viruses with envelopes from different phases of infection demonstrate similar replication in α4β7 high CD4+ T cells. Scatter plots show relative light units in TZM-bl cells infected with 50 ul of virus supernatants recovered from virus exposed FACS confirmed α4β7 high CD4+ T cells (A – D). Each symbol represents mean of 3 independent RLU measurements. Scatter plots show number of RNA copies recovered from virus exposed FACS confirmed α4β7 high CD8+ T cells from 4 different HIV-1 seronegative donors (E - H). Each symbol represents mean of 2 independent RNA copy quantifications. Similar to Figure 2, in the early and chronic group unique symbols are used to show the longitudinal changes within an injection drug user. In each scatterplot, the lines denote the median. Significant differences (p ≤0.05) are indicated with a star in the graphs. Symbols in gray denote virus stocks shown to be able to utilize the CXCR4 receptor.