ID | Months after first sample | Protease amino acid 4-99 | Reverse transcriptase amino acid 41-230 | ||||
---|---|---|---|---|---|---|---|
Baseline | Reversion | Additional mutations | Baseline | Reversion | Additional mutations | ||
Transmitted variants harboring only NRTI-related mutations | |||||||
P01 | 0 | S37N L63P I93L | Â | Â | M41L V60I I135T S162C K166R R211G L214F | Â | Â |
 | 10 |  |  |  |  | -K166R | +V106IV |
 | 16 |  |  |  |  |  | V106IV > I |
P02 | 0 | T12A K14KR Q18HQ L19IL S37N L63P I93L | Â | Â | M41L V60I I135T S162G K166EK I167F R211G L214F | Â | Â |
 | 12 |  | -K14KR, −Q18HQ | L19IL > IKLQ |  | -S162G -I167F | K166EK > KR |
 | 28 |  | T12A > AT | L19IKLQ > IL |  | R211G > GR | +T165IT |
P03 | 0 | T12A I13V L19I S37NS I64V C67CR | Â | Â | M41L V60I F61FS E122K D123E I178L V179IV E203EG Q207EQ L214F | Â | Â |
 | 11 |  | -S37NS -I64V > IV -C67CR | +I62IV |  | -F61FS -E203EG | +S162X V179IV > I Q207EQ > KQ + R211KR |
 | 32 |  | T12A > AT | I62IV > V |  | -S162X -I178L -V179I | Q207KQ > EQ |
P04 | 0 | E35D S37D D60E I62V L63P A71T I72V I93L | Â | Â | K49R V60I V118I E122K D123DE I135R S162D L210LS R211G | Â | Â |
 | 11 |  |  | +I72V > EV |  | -L210LS | D123DE > E S162D > S162X + T200IT + E204EK |
 | 25 |  |  | +T12AT + K14KR + V77IV |  | -S162X, R211G > GR -E204EK | +T165IT |
P05 | 0 | S37N I64V | Â | Â | K64R R83K I178L I202V L214F T215D | Â | Â |
 | 12 |  |  | +M36I |  | -K64R | +S68N + E122K |
 | 99 |  |  | +I13IV + K14KR + K45KR |  | R83K > KR, −I202V | +A158AS + S162T |
P06 | 0 | L10I K14EV S37N L63T E65EV I72T V77I I93L | Â | Â | E122K I142V D177E Q207E L214F T215S | Â | Â |
 | 14 |  |  | K14EV > E E65EV > V |  | -E122K > EK |  |
 | 21 |  |  |  |  |  |  |
P07 | 0 | I15L L19V S37N R41K D60E L63P I72IV I93L | Â | Â | V60I S68G R83K V90I A98S E122P D123DEG I135L S162C D177E I202IV R211K L214F T215D | Â | Â |
 | 11 |  |  | +M36IM |  | −202IV | D123DEG > DE |
 | 27 |  | -M36IM | L19V > IV |  |  | D123DE > DEG + T200IT |
P08 | 0 | L10I S37N R41K I62V L63S V77I I93L | Â | Â | V60I S68G E122K I135V S162NS T165IT Q174HQ G196E R211G L214F T215IT | Â | Â |
 | 13 |  |  |  |  | -S162NS -T165IT-T215IT | Q174HQ > H |
P09 | 0 | S37N I62V L63T I64L V77I | Â | Â | S68T E122K I135V T139A G196E Q197R L214F T215AT | Â | Â |
 | 13 |  |  |  |  | -T139A | +H198HR |
 | 20 |  |  | +R57KR |  | -H198HR | S68T > AT + T139AT + T215AT > A |
P10 | 0 | I15V E35D S37D D60E L63P V77I I93L | Â | Â | S68K T69N A98S L100LV E122K D123E I135R N136NT Q145E S162C I178M E194D I195L G196E T200A I202V Q207K R211G L214F K219N H221Y K223Q | Â | Â |
 | 11 |  |  | +R41K |  | -L100LV -N136NT |  |
 | 44 |  |  | +K45KR + R57KR |  | -I135R | +K49KR |
P11 | 0 | S37H R41KR R57K Q61D | Â | Â | V60I D67N T69E V106I D121Y I135T S162C D177E G196E E203D Q207E R211KR L214F T215C | Â | Â |
 | 13 |  |  |  |  | -V106I L214F > FL | +T200IT |
P12 | 0 | L10I T12S L19I L63T | Â | Â | V60I D67G S68G I135T I178M R211KR L214F T215C K219E | Â | Â |
 | 11 |  | -L10I | L19I > T |  | -R211KR | +E122EK |
 | 24 |  |  | +L10I L19T > I + I62IV |  | -E122EK -I135T | +Q207LQR + R211KR |
P13 | 0 | T12S L19I L63T I64IM | Â | Â | V60I D67G S68G A158S I178M L214F T215C K219E | Â | Â |
 | 12 |  |  | I64IM > M |  |  | +E40Q |
 | 14 |  |  |  |  | -E40Q |  |
P14 | 0 | T12S L19T L63T | Â | Â | V60I D67G S68G I135IT I178M L214F T215C K219E | Â | Â |
 | 14 |  |  |  |  |  | +E122EK I135IT > T |
P15 | 0 | L19I E35D S37N R57KR L63P V77IV I93L | Â | Â | M41LT69S D86DE E122K S162C I178L E204DE Q207EKQ L210E R211K L214F T215ST | Â | Â |
 | 11 |  | -R57KR | V77IV > I |  |  | Q207EKQ > KQR L210E > DE |
 | 39 |  | V77I > IV | S37N > DN + R57KR |  |  | +V60VI + I195IL Q207KQR > x L210DE > E R211K > KN |
 | 77 |  | ’-R57KR |  |  | S162C > CS | E204DE > DEKNR211KN > K |
P16 | 0 | L19I E35D S37NS L63P V77IV I93L | Â | Â | M41L T69S D86E K104KR E122K S162C I178L E204DE Q207KQR L210E R211DEKN L214F T215S | Â | Â |
 | 13 |  |  | I72IM |  | -K104KR | T69S > AS S162C > CW |
 | 33 |  | -I72IM | E35D > DEKN S37NS > N V77IV > I |  | -E204DE | T69AS > S S162CW > W + E194DE Q207KQR > R R211DEKN > D |
 | 49 |  |  | E35DEKN > DE |  | -E194DE | Q207R > QR R211D > DEKN |
P17 | 1 | E35D R41K L63P I93L | Â | Â | K103N E122K D123E R211K L214F | Â | Â |
 | 12 |  |  |  |  |  | +K173KT + D177DN |
 | 30 |  |  | +S37N |  | -K173KT | +Q174HQ + Q207QR R211K > KQ |
Transmitted variants harboring only NNRTI-related mutations | |||||||
P18 | 0 | L10IV I13IV I15IV L19IL I62V L63PS I64LV C67S V77I | Â | Â | K64R K103N E122K D123E K173EK Q174QR V179I T200A R211K L214F | Â | Â |
 | 12 |  | -L19IL | L10IV > I L63PS > X I64LV > V |  | -K173EK -Q174QR | +D177DN |
 | 28 |  |  |  |  |  | +R72RS + Q174QR |
P19 | 0 | L10I I15V S37T R41K C67G G68E H69R | Â | Â | V60I K103Q E122K D123E I142V R211K L214F | Â | Â |
 | 10 |  |  |  |  |  |  |
 | 12 |  |  |  |  |  |  |
 | 59 |  |  | G68E > D |  |  | + T200IT |
P20 | 0 | T12N K14R S37N R41KR I64V | Â | Â | E122K D123E I135T Y181C T200A I202V R211K L214F | Â | Â |
 | 11 |  | S37N > NS |  |  |  |  |
 | 49 |  | K14R > KR -R41KR | +E35D S37NS > N + L63HQ |  | E122K > EK I135T > IT | D123E > AE |
P21 | 0 | I13V S37NT L63P A71AG | Â | Â | I50N G51W P52A V60IV R83K A98AG K101H S105LS D177E V179I G190A R211K L214F | Â | Â |
 | 10 |  | -A71AG | S37NT > NST |  | -I50N -G51Q -P52A -A98AG -S105LS | V60IV > I + E122K K173EK |
P22 | 0 | I13V M36T S37N L63P | Â | Â | S48Q R83KR K101H D123DE D177E V179I G190A L214F H235R | Â | Â |
 | 13 |  |  | M36T > IMT |  | -S48Q -H235R | D123DE > DEKN + S162CS |
P23 | 0 | S37N M46L D60E I62V L63S I72V V77I I93L | Â | Â | K49R V60I V118I I135R E169D R211G L214F | Â | Â |
 | 14 |  |  |  |  |  | +F87FL + E204EK |
 | 22 |  |  |  |  | V60I > IV -F87FL -E204EK |  |
P24 | 0 | E35DE S37N M46L D60E I62V L63S I93L | Â | Â | K49KR V60I V118I E122K I135R R211G | Â | Â |
 | 10 |  | -E35DE -I93L | +K70KR |  | -K49KR |  |
 | 29 |  | -K70KR |  |  |  | +K104KR + S162C |
P25 | 0 | E35D S37N M46L D60E I62V L63S I93L | Â | Â | K49R V60I V118I E122K I135R R211G | Â | Â |
 | 14 |  |  | +R41KR |  |  | +D123E |
 | 23 |  |  | L63S > PS I93L > IL |  |  | D123E > DEKN + I178ILV |
Transmitted variants harboring only PI-related mutations | |||||||
P26 | 0 | E35D S37N M46L D60E I62V L63S I93L | Â | Â | K49R V60I V118I E122K D123DN I135R R211G | Â | Â |
 | 14 |  |  | +L19IL |  | -D123DN | +T165IT |
 | 26 |  |  | L19IL > X + A71AV |  |  | T165IT > I + E204EK |
P27 | 0 | E35D S37N M46L D60E I62V L63S I93L | Â | Â | K49R V60I V118I E122K I135R N136NT S162NS I167IT R211G | Â | Â |
 | 13 |  |  | L63S > APS |  | -N136NT -S162NS -I167IT |  |
 | 38 |  | -E35D | L63APS > A |  |  |  |
P28 | 0 | L19T S37N L63P L90M I93L | Â | Â | E122KT200A L214F K220X | Â | Â |
 | 13 |  | S37N > NS |  |  | -K220X |  |
Transmitted variants harboring mutations against two drug classes | |||||||
P29 | 0 | T4IT T12S L19IV L63X | Â | Â | V60I D67G S68G K70KR I178M Y181CY L214F T215C K219E | Â | Â |
 | 10 |  | -T4IT | +L10I L19IV > I L63X > T |  | -K70KR -Y181CY | +I135IT + E204EG + R211KR |
 | 46 |  | -L10I | T12S > PS + G16AG L19I > IV + M36IM L63T > PT + I64IV |  | -E204EG -R211KR | I135IT > T |
P30 | 0 | L10I I13V I15V I62V L63P G73S L90M | Â | Â | V60I A98S K103N D121Y D123E I135T R172KR L214F | Â | Â |
 | 12 |  | -G73S |  |  | I135T > IT -R172KR |  |
 | 18 |  |  | +S37NS |  |  | +K102KR |
P31 | 0 | L10I I15V K20R E35D M36I S37N I54V Q58E L63P A71V V82A L90M | Â | Â | M41L K43N V60I D67N E122P I135T E138A I142V L210W R211M L214F T215D | Â | Â |
 | 10 |  |  | +F53FL |  | -L214F | +T139I + I178IV |