Figure 4
From: Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation
Association of the T242N mutation with the viral load. The viral load set points were stabilized from ~100 days after screening in five HIV-1 infected subjects. The T cell escape mutation T242N was selected in vivo in subjects CH77 and CH58. CH131 was infected with the T242N escape mutant. The time for the first detection of the T242N escape mutation (blue and brown) or the N242T reversion mutation (red) is indicated by open triangle and the time for the fixation of the T242N or N242T mutation in the viral population is indicated by solid triangle. No T242N mutation was detected in CH40 and CH470.