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Table 1 Effects of the H171T IN substitution on antiviral activities of BI-D

From: The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

  Producer cells Target cells LEDGF KO producer cells LEDGF KO target cells
  EC 50(μM) Fold change EC 50(μM) Fold change EC 50(μM) Fold change EC 50(μM) Fold change
WT IN 0.090±0.031a -- 1.17±0.1a -- 0.080±0.01 -- 0.067±0.02 --
H171T IN 6.11±0.63 67.9x 12.4±0.85 10.6x 2.20±0.64 28x 2.98±0.7 44.5x
  1. Means±S.D. are shown for at least 3 independent experiments.
  2. aData from Ref [39].