Table 1 Effects of the H171T IN substitution on antiviral activities of BI-D
Producer cells | Target cells | LEDGF KO producer cells | LEDGF KO target cells | |||||
|---|---|---|---|---|---|---|---|---|
EC 50(μM) | Fold change | EC 50(μM) | Fold change | EC 50(μM) | Fold change | EC 50(μM) | Fold change | |
WT IN | 0.090±0.031a | -- | 1.17±0.1a | -- | 0.080±0.01 | -- | 0.067±0.02 | -- |
H171T IN | 6.11±0.63 | 67.9x | 12.4±0.85 | 10.6x | 2.20±0.64 | 28x | 2.98±0.7 | 44.5x |