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Figure 1 | Retrovirology

Figure 1

From: HIV-2 interaction with cell coreceptors: amino acids within the V1/V2 region of viral envelope are determinant for CCR8, CCR5 and CXCR4 usage

Figure 1

HIV-2 MIC97 and HIV-2 MJC97 use CCR8 as coreceptor to infect GHOST-CD4 cells and PBMC. PBMC and GHOST-CD4 cell lines expressing different coreceptors were exposed to 100 TCID50 of each virus; viral replication was quantified by RT activity in culture supernatants during a 12-day period after infection and the highest value of RT activity observed during this time period was used. Results are expressed as the mean of three independent experiments performed in duplicate. Error bars represent the standard error of the mean. A star (*) indicates statistical significant difference (p < 0.001) between the means of peak RT activity measured in culture supernatants of GHOST-CD4/CCR8 inoculated with HIV-2MIC97 and HIV-2MJC97, compared with GHOST-CD4/CCR5, GHOST-CD4/CXCR4, GHOST-CD4/CX3CR1, and GHOST-CD4/Hi5 inoculated with the same viruses.

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Retrovirology

ISSN: 1742-4690

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