Figure 4
From: Neutralisation of HIV-1 cell-cell spread by human and llama antibodies
Enhanced potency of full-length HCAb antibodies. (A) IC50μM for the mono-specific bivalent J3-Fc in comparison to J3 alone for the viruses listed. Very potent neutralisation (<0.001) is indicated in dark grey; potent neutralisation (0.001-0.01) in grey, intermediate neutralisation in light grey (0.01-0.5) and weak neutralisation in white (>0.5). IC50 values were generated from duplicate titrations of J3 and J3-Fc onto TZM-bl cells as described in the methods. (B) Fold increase in IC50 for J3-Fc relative to J3 for indicated viruses. The subtype/CRF of each individual virus is indicated on the X axis.