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Table 2 Env-specific antibodies of the IgA class were incubated purified HIV-1 and particle size determined by dynamic light scattering

From: Aggregate complexes of HIV-1 induced by multimeric antibodies

Assessment of aggregation of HIV-1BaLby IgA-class mAbs specific for Env
Antibody Isotype Virus Aggregation1 Δ Viral Size (nm) PDI
2F5 IgG - 14.6 0.19
dIgA ++ 75 0.63
pIgM + 32.1 0.41
b12 IgG - 12.7 0.27
dIgA ++ 63 0.67
ACL4 mIgA + 26.9 0.29
E10 mIgA - 17.3 0.36
XA1 mIgA - -4.1 0.21
  1. The change in the size of viral particles from virus alone (150.2 nm), and the polydispersity index (PDI) of virus-Ab preparations assesses the presence of aggregates.
  2. 1Aggregate formation was scored by the maximum size measured: ++ for Δ > 50 nm; + for 25 ≤ 50 nm; - for ≤ 25 nm.