Figure 4
From: dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
LC-MS/MS analysis of single and dual VLP treated MDMs. MDM donors were treated with a single or dual VLP. Cellular lysates were analyzed by LC-MS/MS analysis. Fold changes in deoxynucleoside metabolites (A) dNTPs, (B) dNDP, and (C) dNMP, are plotted for the single VLP treatment for two MDM donors. # denotes metabolites below the level of detection for LC-MS/MS analysis. Filled circles indicate metabolites that could not be accurately determined due to overlaying peaks with another unidentified metabolite. Three MDM donors treated with dual VLP have fold changes plotted (D) dNTP, (E) dNDP, and (F) dNMP levels.