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The levels of apostosis markers in different HIV infected patients groups
Retrovirology volume 9, Article number: P20 (2012)
Introduction
HIV-1 infection is characterized by a progressive loss of CD4+ T cells. The role of apoptotic processes was identified recently, but a limited information is available so far. The aim of this study was to compare levels of apoptosis markers - cytokeratin 18 neoepitope (CK18) and cytochrome C (CC) in different HIV infected patient groups.
Methods
There were 69 HIV infected patients enrolled in the study and divided into four groups according to CD4+ T cell count and presence of opportunistic infections (OI): 19 patients with CD4+ T cell count above 200 c/mcl without OI, 15 patients with CD4+ T cell count below 200 c/mcl without OI, 7 patients with CD4+ T cell count above 200 c/mcl with OI, 28 patients with CD4+ T cell count below 200 c/mcl with OI. Opportunistic infections included tuberculosis, cryptococcosis, CMV infection, PCP. The serum levels of cytokeratin 18 neoepitope and cytochrome C were determined. Comparisons between groups were made using paired T- test.
Results
CC levels were not significantly different between groups with CD4+ cell count above and below 200 c/mcl (with opportunistic infections 0,5>p>0,4, without opportunistic infections p=0,5). Levels of CC were not significantly influenced by presence of opportunistic infections (with CD4+ cell count above 200 c/mcl p=0,6, with CD4+ cell count below 200 c/mcl p=0,7). We found significant diference of CK18 levels between group without opportunistic infections and CD4+ cell count above 200 c/mcl (210,58 ±26,98 u/l) and group without opportunistic infections and CD4+ cell count above 200 c/mcl (132,95±14,09 u/l), p=0,02, as well as between group without opportunistic infections and CD4+ cell count below 200 c/mcl (132,95±14,09 u/l) and group with opportunistic infections and CD4+ cell count below 200 c/mcl (174,56±20,83 u/l), 0.02>p>0.01.
Conclusion
The results obtained from our study demonstrate elevation of levels of apoptosis serum markers early in HIV infection which anticipate further decrease of CD4 cell count.
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Ilze Eksteina, Valentina Sondore contributed equally to this work.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Eksteina, I., Sondore, V., Rozentale, B. et al. The levels of apostosis markers in different HIV infected patients groups. Retrovirology 9 (Suppl 1), P20 (2012). https://doi.org/10.1186/1742-4690-9-S1-P20
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DOI: https://doi.org/10.1186/1742-4690-9-S1-P20
Keywords
- Infectious Disease
- Tuberculosis
- Serum Level
- Cell Count
- Cancer Research