Volume 9 Supplement 1
Subclinical atherosclerosis in young persons horizontally infected with HIV-1 during infancy
© Cupsa et al; licensee BioMed Central Ltd. 2012
Published: 25 May 2012
To evaluate subclinical atherosclerosis and to identify the cardiovascular risk (CVR) profile in young adults horizontally infected with HIV-1 during infancy.
Retrospective randomized study carried out between 31.12.2009 and 30.06.2010 on 56 HIV infected persons(HIP) parenterally infected with HIV-1 during 1988-1990, following ART, under surveillance of HIV/AIDS Regional Center – Craiova. Variables followed: history and clinical data, traditional and additional CVR factors, metabolic, immunological and virusological parameters, inflammation markers (hs-CRP), ultrasound data regarding carotid intima-media thickness (IMT). Twenty-six HIV-seronegative young adults were assigned as control group (CG) for metabolic parameters, hs-CRP and IMT.
General characteristics of the group: average age = 20.82 ± 1.1 years, equal distribution by gender, 47 HIP (83.93%) classified as clinical and/or immunological AIDS, 26 HIP (46.43%) with CD4>500/mm3, 40 HIP (71.43%) with undetectable RNA-HIV when evaluated, average ART duration = 9.09 ± 3.2 years, average number of ART regimens = 3.2 ± 1.63, 40 HIP (71.43%) experienced to protease inhibitors (PIs). In HIP – hs-CRP = 2.17 mg/l, equivalent with a moderate CVR, statistically different compared with CG (p<0.0001); IMT = 0.76 ± 0.12 mm in HIP vs 0.6 ± 0.11 mm in CG. From the traditional CVR factors dyslipidemia levels were higher in the HIP group vs. CG (p<0.0001). In HIP, linear analysis of the evaluated parameters identified direct correlations between hs-CRP- erytrocites sedimentation rate (ESR) (p=0.04), number of ART regimens and PIs exposure (p=0.007), IMT (p=0.000) and HIV-RNA (p=0.000) and also between IMT – triglycerides (p=0.004), PIs exposure (p=0.004), CD8+ (p=0.0000) and HIV-RNA (p=0.001).
Young HIP have had an average value of hs-CRP equivalent with a moderate CVR; the CVR profile in young seropositive infected with HIV-1 during infancy includes elevated triglycerides, ESR, CD8+, HIV-RNA values and long time of PIs exposure. IMT in young HIP experienced to ART suggests a premature "aging" of the vessel by about two decades.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.