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Open Access

Human papilloma viruses

  • Denise A Galloway1
Retrovirology20129(Suppl 1):I23

https://doi.org/10.1186/1742-4690-9-S1-I23

Published: 25 May 2012

Keywords

Infectious DiseaseCancer ResearchCervical CancerHuman Papilloma VirusPapilloma

A group of approximately 13 human papillomaviruses (HPVs) are responsible for virtually all cervical cancers as well as the majority of vulvar, vaginal anal and penile cancers, as well as at least half of oropharyngeal cancers. Currently two prophylactic vaccines are highly efficacious in preventing HPV 16 and 18 associated disease, and the quadrivalent vaccine also prevents HPV 6 and 11 warts. Currently therapeutic vaccines targeting the viral E6 and E7 oncogenes are being developed. One topic that will be discussed is whether the prophylactic vaccine can have utility in any setting where individuals are already infected. Secondly, this review will discuss the basis of long-term immunity and whether it is afforded by both vaccination and natural infection. Finally, strategies to provide more broad based coverage to other HPV types will be discussed.

Authors’ Affiliations

(1)
Fred Hutchinson Cancer Research Center, Seattle, USA

Copyright

© Galloway; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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