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Table 2 Anti-HIV-1 and -HIV-2 activity and cytostatic properties of WDO-217 in human T-lymphocyte (CEM) cells

From: A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions

Compound

EC50(μM)

CC50(μM)

HIV-1 IIIB

HIV-2 ROD

WDO-217

8.3 ± 1.8

15 ± 6.7

94 ± 15

AZT

0.058 ± 0.030

0.055 ± 0.020

>125

  1. EC 50 : effective concentration or concentration required to protect CEM cells against the cytopathogenicity of HIV by 50%.
  2. CC 50 : cytotoxic concentration or concentration compound required to reduce CEM cell proliferation by 50%.
  3. Values are the mean ± std dev of about 2 to 3 independent experiments.
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Retrovirology

ISSN: 1742-4690

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