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Table 2 Estimated fitness according to the fitness landscape models

From: Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

Factors Subtype B patients (N = 1599) TDR (N = 151) Wild-type (N = 1446) p-value
log10F PI 0.38 (0.24 – 0.56) 0.44 (0.26 – 0.66) 0.38 (0.24 – 0.56) 0.001
log10FPIm 0.38 (0.24 – 0.55) 0.41 (0.25 – 0.57) 0.38 (0.24 – 0.56) 0.427
log10F RTI 0.04 (-0.03 – 0.11) 0.14 (0.03 – 0.27) 0.03 (-0.03 – 0.10) < 0.001
log10FRTIm 0.04 (-0.03 – 0.11) 0.08 (0.01 – 0.17) 0.03 (-0.03 – 0.11) < 0.001
  1. Log10F PI is the estimated PR fitness and log10FPImis the estimated PR fitness when the influence of major resistance mutations on fitness is excluded. Same nomenclature applies to fitness estimates of RT. Data are expressed as median values with the interquartile range between brackets.