Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

Table 2 Estimated fitness according to the fitness landscape models

Factors	Subtype B patients (N = 1599)	TDR (N = 151)	Wild-type (N = 1446)	p-value
log₁₀F_PI	0.38 (0.24 – 0.56)	0.44 (0.26 – 0.66)	0.38 (0.24 – 0.56)	0.001
log₁₀F_PI−m	0.38 (0.24 – 0.55)	0.41 (0.25 – 0.57)	0.38 (0.24 – 0.56)	0.427
log₁₀F_RTI	0.04 (-0.03 – 0.11)	0.14 (0.03 – 0.27)	0.03 (-0.03 – 0.10)	< 0.001
log₁₀F_RTI−m	0.04 (-0.03 – 0.11)	0.08 (0.01 – 0.17)	0.03 (-0.03 – 0.11)	< 0.001

Log₁₀F_PIis the estimated PR fitness and log₁₀F_PI−mis the estimated PR fitness when the influence of major resistance mutations on fitness is excluded. Same nomenclature applies to fitness estimates of RT. Data are expressed as median values with the interquartile range between brackets.

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