Figure 2
From: From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication
Interaction of WRN and RHA with the TAR/Tat complex. (A) Domain structures of RHA and WRN. The amino acid positions of each illustrated domain are indicated. dsRBD, double-stranded RNA-binding domain; RG-rich, arginine (R) and glycine (G)-rich region; EXO, exonuclease domain; RQC, RecQ Conserved domain; HRDC, helicase RNase D C-terminus domain. (B) WRN interacts with Tat and helps the recruitment of the P-TEFb complex (consisting of CycT1 and CDK9) to the HIV-1 promoter. RHA binds to the stem of TAR RNA via its dsRBD and also interacts with WRN. TRBP, TAR RNA binding protein.