Table 2 Logistic Regression for predicting transmission based on number of glycosites in the variable loops
From: Application of a case–control study design to investigate genotypic signatures of HIV-1 transmission
Univariate Odds Ratio (95% confidence interval) | p-value | Odds Ratio with subtype interaction (95% confidence interval) | p-value | Test for Homogeneity between subtype, p-value | Wilcoxon Rank Sum p-value | ||
|---|---|---|---|---|---|---|---|
PNGs in V1 loop | PNGs in V1 loop | ||||||
1 to 2 | Subtype B 1 to 2 | 0.109 | |||||
3 | 1.11 (0.59, 2.06) | 0.751 | 3 | 1.42 (0.55, 3.62) | 0.466 | ||
≥ 4 | 1.62 (0.83, 3.14) | 0.155 | ≥ 4 | 2.29 (0.83, 6.36) | 0.111 | ||
Subtype C 1 to 2 | 0.931 | ||||||
3 | 0.66 (0.18, 2.48) | 0.541 | |||||
≥ 4 | 0.54 (0.14, 2.10) | 0.371 | 0.347 | ||||
PNGs in V2 loop | PNGs in V2 loop | ||||||
0 to 1 | Subtype B 0 to 1 | 0.533 | |||||
2 to 3 | 0.75 (0.44, 1.27) | 0.282 | 2 to 3 | 0.84 (0.44, 1.63) | 0.615 | ||
Subtype C 0 to 1 | 0.323 | ||||||
2 to 3 | 0.67 (0.22, 2.13) | 0.506 | 0.509 | ||||
PNGs in V3 loop | PNGs in V3 loop | * | |||||
0 | Subtype B 0 | 0.024 | |||||
1 | 2.56 (0.49, 13.43) | 0.267 | 1 | ||||
Subtype C 0 | 0.155 | ||||||
1 | 0.008 | ||||||
PNGs in V4 loop | PNGs in V4 loop | ||||||
0 to 1 | Subtype B 0 to 1 | 0.572 | |||||
2 | 0.51 (0.23, 1.14) | 0.102 | 2 | 0.36 (0.10, 1.31) | 0.122 | ||
≥ 3 | 0.54 (0.25, 1.20) | 0.133 | ≥ 3 | 0.46 (0.13, 1.60) | 0.219 | ||
Subtype C 0 to 1 | 0.329 | ||||||
2 | 1.83 (0.35, 9.60) | 0.473 | |||||
≥ 3 | 1.19 (0.22, 6.28) | 0.842 | 0.001 |