Figure 1
From: The trinity of the cortical actin in the initiation of HIV-1 infection
Model of actin dynamics in HIV-1 infection of T cells. Binding of gp120 to CD4 T cells activates Rac-PAK-LIMK-cofilin pathway, triggering early actin polymerization, transiently blocking CXCR4 internalization. Actin-anchoring proteins such as moesin and filamin-A may also serve to anchor the cortical actin to the plasma membrane to facilitate fusion. Following entry, the viral preintegration complex is directly anchored onto the cortical actin for reverse transcription and intracellular migration, which is promoted by cofilin-mediated actin treadmilling.