Figure 3

Acute SIV infection induces an increase in total plasma cells in the intestinal LP with a dominant IgG/M over IgA response. (A) Duodenal sections from controls (Ctl left panels) and macaques infected for 28 days (28 dpi, right panels) were stained with IRF4 mAb, IgA, IgG and IgM polyclonal Ab. Staining of one representative section for each group of macaques is shown. Magnification x200 and x1000 for enlarged images. (B, C) Each symbol corresponds to the mean number of IgA, IgG and IgM plasma cells in LP of duodenum (B) and terminal ileum (C) from one macaque. Bars represent median values for each group. * p values <0.05 (Mann–Whitney, one tailed).