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Table 1 Resistance development in virus isolates exposed to increasing amounts of miniCD4

From: MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

Virus miniCD4 day of harvest mutations found resistant virus
BaL M48 14 none found  
   21 H105H/Y mix  
   28 nd  
   42 H105Y rM48BaL_a
BaL M48U1 14 none found  
   21 nd  
   28 nd  
   36 S375R  
   45 S375R rM48U1BaL_a
BaL M48U1 14 nd  
   20 S375S/N mix  
   27 nd  
   35 nd  
   48 S375R rM48U1BaL_b
SF162 M48 14 D474D/N mix  
   21 D474D/N mix  
   28 D474N  
   57 D474N rM48SF162_a
SF162 M48 13 nd  
   25 nd  
   58 D474N rM48SF162_b
SF162 M48U1 14 S375S/R mix  
   22 S375R  
   28 nd  
   59 G335R, S375R, G471R rM48U1SF162_a
SF162 M48U1 14 V255M, L494L/V mix  
   21 V255M, L494V  
   28 V255M, S375N, L494V  
   57 V255M, S375N, L494V rM48U1SF162_b
SF162 M48 + M48U1 14 D474N  
   21 D474N  
   29 nd  
   50 D474N rCombiSF162_a
SF162 M48 + M48U1 13 nd  
   25 nd  
   34 D474N, L494L/V  
   58 G471E, D474N, L494V rCombiSF162_b
  1. Numbering used is according to the HxB2 sequence. nd: not done.