Table 1 Resistance development in virus isolates exposed to increasing amounts of miniCD4
Virus | miniCD4 | day of harvest | mutations found | resistant virus |
|---|---|---|---|---|
BaL | M48 | 14 | none found | Â |
| Â | Â | 21 | H105H/Y mix | Â |
| Â | Â | 28 | nd | Â |
| Â | Â | 42 | H105Y | rM48BaL_a |
BaL | M48U1 | 14 | none found | Â |
| Â | Â | 21 | nd | Â |
| Â | Â | 28 | nd | Â |
| Â | Â | 36 | S375R | Â |
| Â | Â | 45 | S375R | rM48U1BaL_a |
BaL | M48U1 | 14 | nd | Â |
| Â | Â | 20 | S375S/N mix | Â |
| Â | Â | 27 | nd | Â |
| Â | Â | 35 | nd | Â |
| Â | Â | 48 | S375R | rM48U1BaL_b |
SF162 | M48 | 14 | D474D/N mix | Â |
| Â | Â | 21 | D474D/N mix | Â |
| Â | Â | 28 | D474N | Â |
| Â | Â | 57 | D474N | rM48SF162_a |
SF162 | M48 | 13 | nd | Â |
| Â | Â | 25 | nd | Â |
| Â | Â | 58 | D474N | rM48SF162_b |
SF162 | M48U1 | 14 | S375S/R mix | Â |
| Â | Â | 22 | S375R | Â |
| Â | Â | 28 | nd | Â |
| Â | Â | 59 | G335R, S375R, G471R | rM48U1SF162_a |
SF162 | M48U1 | 14 | V255M, L494L/V mix | Â |
| Â | Â | 21 | V255M, L494V | Â |
| Â | Â | 28 | V255M, S375N, L494V | Â |
| Â | Â | 57 | V255M, S375N, L494V | rM48U1SF162_b |
SF162 | M48 + M48U1 | 14 | D474N |  |
| Â | Â | 21 | D474N | Â |
| Â | Â | 29 | nd | Â |
| Â | Â | 50 | D474N | rCombiSF162_a |
SF162 | M48 + M48U1 | 13 | nd |  |
| Â | Â | 25 | nd | Â |
| Â | Â | 34 | D474N, L494L/V | Â |
| Â | Â | 58 | G471E, D474N, L494V | rCombiSF162_b |