Figure 5

Close-up views of both V255M and S375R mutants in interaction with M48U1. (A) Close-up of the Val255 residue in space fill (left) and of the mutant Met255 residue in space fill (right) showing a steric clash with the cyclohexylmethoxy moiety at the para position of phenylalanine 23 of M48U1 in red stick representation. (B) Close-up of the Ser375 residue in space fill (left) and of the mutant Arg375 residue in space fill (right) showing a steric clash with the cyclohexylmethoxy moiety at the para position of phenylalanine 23 of M48U1 in red stick representation. This drawing was made using PyMOL with coordinates that can be found at pdb accession codes [PDB:2I60] and [PDB:3JWD].