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Table 1 In situ RNA hybridization (ISH) results from tissues of SIVmne infected pigtail macaques

From: Vpx is Critical for SIVmne infection of pigtail macaques

SIVmne virus Vpx-WT ΔVpx Vpx: y-a Vpx: 102
Macaque No. 27617 27614 27616 27613 27618 27615 28487 28486
Virus Loads
Peak VL (x 10-6 copies/ml) 230 200 3.1 0 0.2 4.4 0.3 0
VL at Necropsy (x 10-6 copies/ml) 93.5 19.9 3.1 0 0.2 1.5 0 0
CD4 counts
day 0 1057 2053 1277 2179 1823 1511 819 1176
day 10 955 808 2284 2615 2302 1802 1139 1212
day 21 1109 2740 1531 2818 1954 1701 460 869
day 42   1280   3547   1189 864  
ISH in Tissue
Rectum + (LP, GALT) ND + 0 0 0 0 0
Colon + (LP, GALT) ND + (GALT) 0 0 0 0 0
Cecum + (LP, GALT) ND + (GALT) 0 0 0 0 0
Ileoceccal Junction + (LP, GALT) ND + (GALT/LP) 0 + (GALT) + (GALT) 0 0
Ileum + ND 0 0 + (GALT) 0 0 0
Jejunum + (LP, GALT) ND + (GALT) 0 0 0 0 0
Mesenteric Node ND + + 0 0 0 0 0
Spleen + ND + (and LN) 0 0 + 0 0
Peripheral Node + ND + + 0 + 0 0
  1. ISH was scored as +, SIV RNA expressing cells present; 0, SIV RNA expressing cell not present; ND, not done
  2. Abbreviations: GALT, gut associated lymphoid tissue; LN, lymph node; LP, lamina propria;