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Table 3 Effect of pre-incubation of the virus with inactivators or inhibitors on inhibition of HIV-1 replication

From: A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Preincubation time (min) IC50 ( nM ) for inhibiting HIV-1 Bal infection
D1D2 2DLT T20 T1144
0 137.10 ± 6.66 11.85 ± 2.23 32.35 ± 6.86 2.92 ± 1.01
15 129.25 ± 7.22 7.52 ± 3.65 27.35 ± 3.26 2.71 ± 0.98
60 103.27 ± 6.26 3.22 ± 1.20 20.13 ± 4.21 2.61 ± 0.58
240 86.69 ± 6.13 2.38 ± 0.59 20.51 ± 3.22 2.22 ± 0.82
  1. * Data are representative of two similar experiments tested in triplicate (mean ± SD).