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Table 3 Effect of pre-incubation of the virus with inactivators or inhibitors on inhibition of HIV-1 replication

From: A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Preincubation time (min)

IC50 ( nM ) for inhibiting HIV-1 Bal infection

D1D2

2DLT

T20

T1144

0

137.10 ± 6.66

11.85 ± 2.23

32.35 ± 6.86

2.92 ± 1.01

15

129.25 ± 7.22

7.52 ± 3.65

27.35 ± 3.26

2.71 ± 0.98

60

103.27 ± 6.26

3.22 ± 1.20

20.13 ± 4.21

2.61 ± 0.58

240

86.69 ± 6.13

2.38 ± 0.59

20.51 ± 3.22

2.22 ± 0.82

  1. * Data are representative of two similar experiments tested in triplicate (mean ± SD).
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Retrovirology

ISSN: 1742-4690

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