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Table 1 Inactivation of cell-free HIV-1 R5 and X4 strains by 2DLT

From: A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

HIV-1 strain (subtype, tropism) EC50 (nM)
D1D2 2DLT T1144 T20
Bal (B, R5) 157.2 ± 34.2 24.5 ± 2.25 >500 >500
IIIB (B, X4) 51.2 ± 9.21 17.3 ± 1.62 >250 >250
92US657 (B, R5) 319.2 ± 56.1 48.7 ± 14.5 >500 >500
93 MW959 (C, R5) 478.2 ± 89.3 78.6 ± 7.04 >500 >500
92TH009 (E/A, R5) 209.5 ± 6.1 69.9 ± 14.4 >500 >500
  1. * Data are representative of two similar experiments tested in triplicate (mean ± SD).