Volume 8 Supplement 1

15th International Conference on Human Retroviruses: HTLV and Related Viruses

Open Access

HLA allele distributions and associations in a cohort of LTNPs from China

  • Mohammad A Rai1Email author,
  • Stella Chun Hao1,
  • Marie-Eve Blais1,
  • T Rostron1,
  • Y Zhang2,
  • KY Xu2,
  • H Yan2,
  • Andrew J McMichael1,
  • T Dong1 and
  • Sarah Rowland-Jones1
Retrovirology20118(Suppl 1):A84

https://doi.org/10.1186/1742-4690-8-S1-A84

Published: 6 June 2011

Background

Various studies have shown that HLA polymorphisms are associated with susceptibility/resistance to HIV-1 infection, and therefore influence the rate of disease progression of HIV/AIDS in individuals of different ethnic backgrounds. Association of HLA with HIV/AIDS has been studied extensively within Caucasians and Africans. However, limited data are available from China.

Methodology

HIV Positive Samples were collected from the SM village in Henan province: SM Cohort. These subjects got infected in the early 90s after taking part in an illegal plasma donation scheme that became contaminated by HIV-1 infection. Our data show that they were infected by a single or a few closely related clade B strains. Control samples collected from a neighboring village. DNA was extracted, HLA-typing done and HLA analysis computed using Arlequin and SAS.

Results

Genetic profile of the cohorts was obtained. On 1 locus: analysis: HLA A*02 (P=0.35), HLA B*15(P=0.02) and HLA B*44(P=0.02) were found to be statistically significant. 2 loci differences include B*13 C*06, B*13 C*06, A*02 C*07, A*24 C*03. 3 loci: A*30 B*13 DRB1*07. Similarly, viral loads and CD4 count associations were computed to find associations co-relating with the HLAs.

Conclusions

This is the first analysis for HLA distribution amongst LTNPs from China, inferring their HLA co-relates with a delayed progression to HIV/AIDS. In our cohort, for slow and long-term non-progressors, there is an enrichment of specific HLAs which appear to be associated with delayed disease progression. Next plan is to initiate T Cell work and also correlate KIR/NK cell responses.

Authors’ Affiliations

(1)
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
(2)
Beijing You An Hospital, Capital Medical University

Copyright

© Rai et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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