- Meeting abstract
- Open Access
HTLV-1 infection and associated diseases in Peruvian twins probably exposed to HTLV-1 mother-to-child transmission
Retrovirology volume 8, Article number: A57 (2011)
Since 1989, our Institute provides HTLV-1 screening to the relatives of newly diagnosed HTLV-1 cases.
We report HTLV-1 infection and associated diseases in twin pairs in which both siblings were tested at ages older than 3.
We identified six pairs of twins. Among four monozygotic pairs, 3 were male; median age at HTLV-1 screening was 19. Two pairs were HTLV-1-negative, one positive, and one discordant. The mother of the concordant positive pair was tested 32 years after twins’ delivery because of strongyloidiasis, and developed Adult-T-cell- leukemia-lymphoma (ATLL). Length of breastfeeding was reported the same for both twins, but not recalled. At age 35 one developed ATLL, the other remained asymptomatic. In the discordant monozygotic pair, length of breastfeeding was not clarified for the negative sibling, and six months for the HTLV-1 positive one; the latter developed crusted scabies at age 15. In the concordant negative pairs, born to mothers who later developed HAM/TSP, each twin was breastfed for less than three months. In the case of dizygotic twins, four female, both pairs were HTLV-1-discordant. In one pair, whose mother was HTLV-1-positive, twins were equally breastfed for six months. In the other pair, only the positive sibling received breastfeeding, for two years. Both positive siblings presented HAM/TSP. According to medical interviews, no other risk factors for HTLV-1-adult transmission were present in these twins.
These findings suggest the interplay of genetic and non genetic factors, including the confirmed role of breastfeeding, on HTLV-1 mother-to-child transmission and HTLV-1-associated diseases.