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  • Meeting abstract
  • Open Access

Viral expression directs the fate of B cells in BLV-infected sheep

  • 1Email author,
  • 1,
  • 1,
  • 1,
  • 2 and
  • 1, 3
Retrovirology20118 (Suppl 1) :A3

https://doi.org/10.1186/1742-4690-8-S1-A3

  • Published:

Keywords

  • Cyclosporine
  • Infected Cell
  • Virus Type
  • Host Immune Response
  • Express Cell

There is a long lasting debate about the latency of human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). Evidence indicates that these viruses are transcriptionally silent and replicate through mitotic division of infected cells (clonal expansion). However, this model is inconsistent with the permanent and vigorous stimulation of the host immune response directed against these viruses.

To address this apparent paradox, we studied the fate of cells in which viral expression was transiently induced. Using a dual fluorochrome labeling approach, we show that virus-positive and negative cell populations have different kinetics in BLV-infected sheep. Furthermore, cyclosporine treatment completely abrogates the difference in kinetics, consistent with a role of the immune response in controlling virus expressing cells.

Authors’ Affiliations

(1)
Cellular and molecular biology, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium
(2)
National Veterinary Research Institute, Pulawy, Poland
(3)
Interdisciplinary Cluster for Applied Genoproteomics, University of Liège, Liège, Belgium

Copyright

© Florins et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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