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  • Meeting abstract
  • Open Access

Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program

  • 1Email author,
  • 1,
  • 1,
  • 1 and
  • 1, 2
Retrovirology20118 (Suppl 1) :A140

https://doi.org/10.1186/1742-4690-8-S1-A140

  • Published:

Keywords

  • Replication Timing
  • Histone Hyperacetylation
  • Minichromosome Maintenance
  • P300 Recruitment
  • Genomic Lesion

The Tax oncoprotein encoded by the Human T-cell leukemia virus type 1 (HTLV-1) plays a pivotal role in viral persistence and pathogenesis. HTLV-1 infected cells proliferate faster than normal lymphocytes, expand through mitotic division and accumulate genomic lesions. Here, we show that Tax associates with the minichromosome maintenance MCM2-7 helicase complex and localizes to origins of replication. Tax modulates the spatiotemporal program of origin activation and fires supplementary origins at the onset of S phase. Thereby, Tax increases the DNA replication rate, accelerates S phase progression but also generates a replicative stress characterized by the presence of genomic lesions. Mechanistically, Tax favors p300 recruitment and histone hyperacetylation at late replication domains advancing their replication timing in early S phase.

Authors’ Affiliations

(1)
National Fund for Scientific Research, Gembloux Agro-Bio Tech, Cellular and Molecular Biology, University of Liège, Gembloux, 5030, Belgium
(2)
National Fund for Scientific Research, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège, Liège, 4000, Belgium

Copyright

© Boxus et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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