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  • Meeting abstract
  • Open Access

Association of interleukin - 18 gene polymorphism with susceptibility or protective effect to HTLV-1 infection

  • 1Email author,
  • 2,
  • 1, 3,
  • 1, 2,
  • 2,
  • 2,
  • 1, 2 and
  • 1, 3
Retrovirology20118 (Suppl 1) :A118

https://doi.org/10.1186/1742-4690-8-S1-A118

  • Published:

Keywords

  • Promoter Region
  • Gene Polymorphism
  • Genotypic Frequency
  • Infected Patient
  • Polymorphic Site

Background

Polymorphisms in promoter region of IL-18 genes have been studied in many chronic inflammatory and infectious disorders. For instance, the IL-18 -137 GG and -607CC polymorphisms have been associated with elevated expression of IL-18, which could contribute for the inflammatory process and favor the antiviral effects of this cytokine. In this study, we evaluated the IL-18 promoter region -137C/G and -607A/C polymorphisms in HTLV-infected patients exhibiting (HAM) or not (HAC) symptomatic disease and in healthy controls.

Methods

The promoter region polymorphic sites (-137C/G and -607A/C) were evaluated by polymerase chain reaction - sequence specific primers (PCR-SSP) analysis using peripheral blood DNA obtained from HAC (54), HAM (44) and healthy control (150) individuals. Proviral load of infected patients (HAC and HAM) was determined by real-time PCR.

Results

The -607CC genotype was less frequent for HAC group (p=0.0501; OR=0.4890; CI=0.2480 to 0.9643), and infected patients (p=0.0232; OR=0.5207; CI=0.3033 to 0.8937) compared to healthy controls. The -607AC genotype was more frequent for HAC group (p=0.0387; OR=1.991; CI=1.043 to 3.801), and infected patients (p=0.0376; OR=1.757; CI=1.047 to 2.948) compared to healthy controls. No significant difference was observed for allelic and genotypic frequencies of the -137C/G among deferments groups. No significant difference was observed for allelic and genotypic frequencies of the -137C/G and -607A/C polymorphisms when correlated with proviral load.

Conclusion

The -607CC (high producer of IL-18) genotype exhibited protective effect against the infection, whereas the -607AC genotype conferred susceptibility to HTLV-1 infection.

Declarations

Acknowledgements

Financial Support: FAPESP, CNPq, CTC/FUNDHERP and INCTC.

Authors’ Affiliations

(1)
Regional Blood Center of Ribeirão Preto, Ribeirão Preto, Brazil
(2)
Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
(3)
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

Copyright

© Wagatsuma et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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