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HTLV-1 bZIP factor perturbs immune response to the pathogens in vivo by inhibiting IFN-gamma production
Retrovirology volume 8, Article number: A102 (2011)
HTLV-1 carriers and the patients with adult T-cell leukemia (ATL) frequently suffer from the opportunistic infections. Although it has been known that HTLV-1 infection evokes cell-mediated immune deficiency, its mechanism remains unknown. HTLV-1 bZIP factor (HBZ) is encoded in the minus strand of HTLV-1, which is constitutively expressed and involved in the proliferation of HTLV-1-infected cells. In this study, we investigated the role of HBZ in immunodeficiency in a mice model. HBZ transgenic (HBZ-Tg) mice were infected with HSV-2 and Listeria monocytogenes and evaluated for cellular immunity to those pathogens. The clearance of both pathogens was impaired in HBZ-Tg mice compared with the non-transgenic littermate. In the both infection, production of IFN-gamma in CD4+ T cells was significantly reduced in HBZ-Tg mice. In addition, ectopic expression of HBZ in primary human CD4+ T cells impaired IFN-gamma production in vitro. As the molecular mechanisms, we found that HBZ suppressed transcription of IFNG promoter. Our results suggest that HBZ plays a crucial role for cellular immunodeficiency in HTLV-1-infected subjects.
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Sugata, K., Satou, Y., Yasunaga, Ji. et al. HTLV-1 bZIP factor perturbs immune response to the pathogens in vivo by inhibiting IFN-gamma production. Retrovirology 8 (Suppl 1), A102 (2011). https://doi.org/10.1186/1742-4690-8-S1-A102
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DOI: https://doi.org/10.1186/1742-4690-8-S1-A102
Keywords
- Leukemia
- Mouse Model
- Opportunistic Infection
- Ectopic Expression
- Listeria