Figure 1

Mutations introduced in the cPPT and/or CTS regions of HIV-1 _LAI . The 223 mutation introduces two pyrimidines in the A-boxes, and the 225T mutant is derived from the 225 mutant, which contains two additional pyrimidines in the G-box. The T mutation refers to the introduction of two cytosines in the T-box. The cPPT-D mutation [9] corresponds to the 225T mutant with 4 additional mutations in A-boxes, totalling to 10 mutations in the 19-mer cPPT. The CTS mutant has a total of 8 mutations in the ter1 and ter2 domains [6]. Numbers indicate amino acid positions in HIV-1 IN.