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Figure 1 | Retrovirology

Figure 1

From: Distinct roles of CD4+T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model

Figure 1

Distinct populations of CD4+ T cells regulate the virus-specific immune response during acute Friend Retrovirus infection. CD4+ helper T cells and follicular helper T cells augment virus-specific cytotoxic T cell and antibody responses. In addition, a subpopulation of effector CD4+ T cells directly inhibits virus replication. However, at the same time natural regulatory T cells expand and start to suppress effector T cell responses, which interferes with control of virus replication. (Arrows indicate enhancement of responses, whereas blocked lines indicate inhibition).

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