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Figure 5 | Retrovirology

Figure 5

From: Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes

Figure 5

Vaccine-induced FV-specific antibody response. CB6F1 mice were prime- and boost-immunized with Ad5 and Ad5F35 based vectors, respectively, encoding F-MuLV Env and Gag with or without co-administration of a specific vectored type I IFN subtype, as indicated. Binding antibodies were analyzed 18 days after boost immunization (A), whereas neutralizing antibodies were analyzed 10 days after FV challenge infection (B). The graphs show the reciprocal titers and horizontal lines mark the mean values. Statistically significant differences (P < 0.05) compared to unvaccinated control mice (*) or mice vaccinated with Env- plus Gag-encoding vectors (#) are indicated. Each dot represents an individual mouse. Data are representative of two independent experiments with similar results.

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Retrovirology

ISSN: 1742-4690

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