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Figure 2 | Retrovirology

Figure 2

From: Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes

Figure 2

Viral loads after FV challenge infection of vaccinated mice. CB6F1 mice were prime- and boost-immunized with Ad5 and Ad5F35 based vectors, respectively, encoding F-MuLV Env and Gag with or without co-administration of a specific vectored type I IFN subtype, as indicated. Three weeks after the boost immunization mice were challenged with FV. Viral loads in the plasma of FV-infected mice were analyzed on day 10 p.c. (A) shows viremia levels as FFU/ml, median values are indicated by lines. On day 21 p.c. the viral loads in spleen were analyzed (B), the graph shows the viral load as IC/spleen, the horizontal lines mark median values. Statistically significant differences (P < 0.05) compared to unvaccinated control mice (*) or mice vaccinated with Env- plus Gag-encoding vectors (#) are indicated. Each dot represents an individual mouse. Data are representative of two independent experiments with similar results.

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Retrovirology

ISSN: 1742-4690

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