Figure 9
From: Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
Chlorhexidine Inhibits HIV-1 Replication in PBMCs. To assess the effect of chlorhexidine on HIV-1 replication, PBMCs were infected with the BaL strain of HIV-1 for 2 h. Subsequently, varying doses of chlorhexidine (0.5-5 μM) were added to the medium. Medium -/+ drug was harvested (A) 3 and (B) 7 days post-infection and level of virus production determined by p24 ELISA. (C) The effect of chlorhexidine treatment on PBMC viability was monitored by trypan blue exclusion on days 3 and 7 post HIV-1 infection.