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Figure 2 | Retrovirology

Figure 2

From: Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues

Figure 2

Predicted alterations in the CD4bs cavity from three-dimensional gp120 models. The gp120 model of Macs2ln5 Env is shown in molecular surface representation, and the CD4 molecule is shown in blue Cα wire, with Phe43 of CD4 highlighted in yellow stick representation to show the "Phe43 cavity" of gp120. gp120 residues in the CD4 binding pocket located within 4 Å of the CD4 molecule are shown in ball and stick representation and their molecular surface is highlighted in blue. The width of the CD4bs aperture, as constrained by the inner-most atoms at the gp120 V1V2 stem and the V5 loop, was deduced as described previously [13].

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Retrovirology

ISSN: 1742-4690

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