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Table 1 Clinical and sampling profiles of patients studied.

From: Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infection

Patient

HLA class I type

Time of last HIV Ab negative test (DFOSx1)

Time of first fully positive HIV Ab test (DFOSx)

First sampling time-point

studied (DFOSx)

Viral load at first PBMC sampling time point

(RNA copies/ml plasma)

Setpoint persisting viral load established after the acute phase of infection (RNA copies/ml plasma)

MM7

A*02

A*03

B*07

B*44

Cw*05

Cw*07

Evolving at 11

16

23

690,000

128,925

MM9

A*01

A*66

B*41

B*08

Cw*07

Cw*07

7

19

19

142,700

19,379

MM12

A*03

A*68

B*07

B*44

Cw*07

Cw*07

ND2

7

16

1,555,700

97,970

MM13

A*01

A*01

B*08

B*57

Cw*06

Cw*07

ND

15

16

131,800

15,348

MM26

A*02

A*68

B*51

B*35

Cw)15

Cw*04

Evolving at 37

49

55

56,200

34,493

MM27

A*02

A*03

B*07

B*44

Cw*05

Cw*07

Evolving at 12

26

28

353,200

48,360

MM28

A*11

A*30

B*13

B*35

Cw*04

Cw*06

6

9

6

4,337,100

12,322

MM33

A*02

A*68

B*07

B*44

Cw*05

Cw*07

Evolving at 9

12

12

1,451,400

73,958

MM34

A*01

A*24

B*51

B*35

Cw*12

Cw*12

Evolving at 10

17

17

29,900

8,522

MM39

A*02

A*03

B*15

B*35

Cw*03

Cw*04

Evolving at 3

23

5

350,600

8,546

MM43

A*02

A*02

B*55

B*40

Cw*10

Cw*09

Evolving at 6

13

21

Not available

(898,100 at 27 DFOSx)

64,565

MM45

A*03

A*03

B*07

B*51

Cw*07

Cw*15

Evolving at 1

22

22

23,200

1,917

MM46

A*02

A*11

B*08

B*52

Cw*07

Cw*12

1

5

5

224,100

81,011

MM47

A*24

A*24

B*39

B*65

Cw*02

Cw*07

Evolving at -1

8

28

17,000

15,839

MM48

A*24

A*26

B*62

B*27

Cw*01

Cw*09

1

Evolving at 16

22

40,100

4,266

MM51

A*02

A*30

B*13

B*44

Cw*05

Cw*06

Evolving at 5

39

18

39,400

26,557

MM55

A*01

A*33

B*14

B*15

Cw*07

Cw*08

6

24

31

1,200

50

MM56

A*02

A*24

B*35

B*57

Cw*04

Cw*06

4

ND

14

15,000

1,023

  1. 1DFOSx = days following onset of symptoms; 2ND = not determined