Figure 7
From: A Functional Role for ADAM10 in Human Immunodeficiency Virus Type-1 Replication
Hypothesized role for ADAM10 during HIV-1 replication, affecting nuclear trafficking. ADAM15 cleaves the ADAM10 extracellular domain, followed by cleavage of the ADAM10 intracellular domain (ICD) by γ-secretase. Data presented in this study support a model whereby release of the ADAM10 ICD from the plasma membrane facilitates HIV-1 replication, either by promoting trafficking/docking of the HIV-1 pre-integration complex (PIC) to the nuclear membrane, or PIC translocation into the nucleus.