Skip to main content

Table 1 Apparent thermodynamic parameters for dissociation of CTD dimers, as determined by ITC dilution experiments at 30°;C in the presence of stapled peptide NYAD-203 with concentration, CI

From: Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

CI/μM Kdiss/μM ΔHdiss/kcal mole-1 200 μM CTD (fm)*
0 15.3 (±3.6) 10.7 (±0.7) 18%
50 31.2 (±6.6) 9.1 (±0.3) 24%
200 33.2 (±3.9) 10.8 (±0.2) 25%
350 40.5 (±6.2) 10.9 (±0.2) 27%
  1. * fm is the estimated fraction of CTD occurring as monomers in solution under these conditions, calculated from the monomer-dimer equilibrium expressions.