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Figure 4 | Retrovirology

Figure 4

From: Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef

Figure 4

HIV-1 localizes with CD81 and tetherin in mature DCs. Localization of HIV-1 with cellular markers within mature DCs was assessed by confocal microscopy. (A) Representative confocal images of localization characteristics of HIV-GFP-Vpr in mDC-LPS; HIV-GFP-Vpr co-localizes with CD81 and tetherin, but not LAMP-1 in mDC-LPS. (B) Pearson's correlation coefficient analysis of mDC-LPS images. (C) Representative confocal images of localization characteristics of HIV-GFP-Vpr in mDC-IFNα; HIV-GFP-Vpr co-localizes with CD81 and tetherin, but not LAMP-1 in mDC- IFNα. (D) Pearson's correlation coefficient analysis of mDC-IFNα images. Numbers on graphic bars indicate the number of cells analyzed. Data presented are the mean ± SEM. Scale bars are 10 μm.

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