Nineteen patients (7 F/12 M; 8 Africans, 1 Asiatic, 11 Caucasians) were submitted to Lpv/r+EFZ during a total period of 618,5 patient-months (33 ± 5 months). These patients were 47 ± 2 years old and are regularly followed for their HIV seropositivity since 123 ± 9 months. Duration of exposure to any ART before inclusion in this study was 92 ± 10 m. Three patients discontinued EFZ rapidly for allergic reactions (2) or psychiatric deterioration (1), and one discontinued after 16 m due to persistently sleep disturbances. Seven patients discontinued for hyperlipemia after 30 ± 5 m. Viral loads remained undetectable (PCR<5 copies RNA/ml) and % CD4 continued to increase to reach a mean value of 25 ± 2%.