At the time of initiation of lopinavir, median age was 54 (37-66). Median duration of HIV infection was 41,6 months (6-101). Previous median duration of treatment was 29 months (4-51). No patient was naïve of treatment. The median previous number of regimens received was 2 (1-2). 5/9 patients were naïve of protease inhibitors. Initial median CD4 cells were 150 (68-478). Viral load (VL) was under the limit of detection in 6 cases. Reasons for switching to lopinavir were toxicity or intolerance (n = 2), absence of efficacy on VL (n = 3) or inadequacy of previous treatment (n = 4). In all cases, lopinavir was given in association of 2 NRTIs.
After a median follow-up of 60 months (18-84), no severe side effect was observed. VL under the limits of detection was obtained for all patients except for one patient with a very poor compliance. In this later case, after switching lopinavir to raltegravir, VL remained undetectable. CD4 increased in all cases. The median gain of CD4 from baseline was + 234 (+50 - +472).