Background
The ATP-binding cassette genes represent the largest family of transmembrane proteins [including multidrug resistant proteins (MRPs) and P-glycoprotein (Pgp)] able to drive the transport of various molecules across cell membranes. Several studies have demonstrated that most of the above transporter are also able to transport antiretrovirals.
The aim of this study was to evaluate whether the antiretroviral treatment might affect the mRNA expression of Pgp and some MRPs.