In our patient followed since the age of 23 (year 1990), an HIV infection repeatedly confirmed by Western Blot assays was never associated with a detectable viremia, or a quantitative drop of CD4+ cell count, while the CD4+ percentage, although proportionally elevated (28-36%), always remained below that of CD8+ lymphocytes, which had only a moderate expansion (52-56%). Rodés et al. [AIDS 2004;18:1109] assessed five "long-term non-progressor" patients with a persistingly negative viremia during 6 years (1997-2003), also demonstrating a reduction of replication capacities related to the retrieval of R5 HIV strains, or the R77Q mutation of viral gene "vpr", while an homozygosis for the delta-32 variant of the CCRC co-receptor was not found. From the immunological point of view, the Author underlined a reduced expansion of CD8+ lymphocyte subset in these five subjects [AIDS 2004;18:1109]. Case reports like ours, although very infrequent and therefore not representative of the entire population of HIV-infected individuals, should deserve in-depth virological and immunological assessment, on the ground of the present, enlarged investigation perspectives, to collect further informations on the network which sustains and allows a so prolonged clinical-immunological HIV infection latency.