The HCV is considered the main etiological agent involved in the hepatitis parenteral transmission. The most frequent genotypes in Brazil are 1, 2 and 3, and genotype 1b is the most frequent in blood donors. Data from the serological screening of the Foundation of Hematology and Hemotherapy of Amazonas (FHEMOAM) show that 0.32% of donors are seropositivity for anti-HCV. Some studies showed that 15 to 25% has good prognostic but 80% develops chronic hepatitis. The purpose study was to describe the clinical course and immunological profile of chronic infection by HCV in patients treated with interferon-alpha and ribavirin.