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Open Access

Serum levels of inflammatory cytokines in leprosy patients

  • Lúcia de Paula1Email author,
  • Isabella Motta Passos1,
  • Rossilene Conceição da Silva1,
  • Adriana Malheiro2,
  • George Allan Villarouco Silva1,
  • Maísa Porto dos Santos1 and
  • Maria da Graça Souza Cunha1
Retrovirology20107(Suppl 1):P190

Published: 11 May 2010


Infectious DiseaseSerum LevelCancer ResearchSignificant RoleImmunosorbent Assay


Measure the serum cytokine levels in untreated leprosy with different parts of the spectrum of leprosy.


Concentrations of IL-4, IL-6 and IL-12 in the serum of patients were determined with a commercially available enzyme-linked immunosorbent assay (ELISA) kit (R&D Systems) according mannufactors instructions.


We observed that mean of IL-4 and IL-6 were higher in lepromatous pole and IL-12 and TNF-α were higher in tuberculoid pole, but only IL-12 were statistic significantly. Our data also demonstrated that most of the patients present very lows or absent levels of TNF-α, IL-4 and IL-6.


This is probably because leprosy is a chronic infectious disease and this profile cytokines is increase acute infections. Thus, studies of cytokine in leprosy have given us a more detailed description of the immunological parameters of the polar types of leprosy and play a significant role in classification and prognosis of this disease.

Authors’ Affiliations

Fundação Alfredo da Matta, Manaus, Brazil
Fundação de Hematologia e Hemoterapia do Amazonas, Manaus, Brazil


© de Paula et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.