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Cervical dysplasia in postmenopausal patients infected by HIV

Background

An increasing number of patients infected with HIV reach the age of menopause. HIV infection is associated with a higher incidence of cervical dysplasia. The aim of our study was to describe cervical abnormalities observed in these patients during menopause.

Methods

Retrospective study at Louis Mourier Hospital, comprising all cervical cytologic and colposcopic examinations in post-menopausal HIV-infected women from 1995 to 2008.

Results

In 18 postmenopausal patients, median age 54 years (range 43 to 63) diagnosed with HIV-1 infection for 7,5 years (range 2 to 25), 51 samples were analyzed. There were 27 (50.98%) abnormalities, including 4 (7,84%) ASC-US, 15 (29.41%) low-grade lesions, and 7 (13.73%) high-grade lesions. Ten of these patients underwent surgery (laser, conization, hysterectomy) during this period. During follow-up, the lesions were stable in 40.48%, regressed in 35,71%, and progressed in 23.81%. In our study, the median onset of high-grade dysplasia during menopause is 5 years.

Discussion

Cervical lesions were frequent in postmenopausal HIV-infected women, mostly low grade and persistant. Women with HIV infection should continue to have gynaecological follow-up, with baseline HPV typing and a yearly Pap tests.

Author information

Correspondence to Pierre-François Ceccaldi.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Infectious Disease
  • Cancer Research
  • Retrospective Study
  • Cervical Lesion
  • Postmenopausal Patient