In 18 postmenopausal patients, median age 54 years (range 43 to 63) diagnosed with HIV-1 infection for 7,5 years (range 2 to 25), 51 samples were analyzed. There were 27 (50.98%) abnormalities, including 4 (7,84%) ASC-US, 15 (29.41%) low-grade lesions, and 7 (13.73%) high-grade lesions. Ten of these patients underwent surgery (laser, conization, hysterectomy) during this period. During follow-up, the lesions were stable in 40.48%, regressed in 35,71%, and progressed in 23.81%. In our study, the median onset of high-grade dysplasia during menopause is 5 years.