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Killer immunoglobulin-like receptor genes and heterosexual HIV-1 transmission
Retrovirology volume 7, Article number: P105 (2010)
Background
Killer immunoglobulin-like receptor (KIR) genes regulate natural killer cell function. KIR gene content has been reported to influence HIV-1 acquisition and progression, but consensus is lacking. We investigated the impact of KIR and KIR/HLA genes on heterosexual transmission in an African cohort.
Methods
Between 1995 and 2006, 566 HIV-1 serodiscordant couples in Zambia, were followed for counseling and serologic testing for a minimum of nine months. KIR genes and HLA alleles were detected by standard typing methods. We tested the association of KIR genes and KIR gene/HLA ligand combinations with HIV-1 transmission and with index partner viral load (VL). All analyses of VL by linear regression were adjusted for age, sex, and time from enrollment. Covariates in proportional hazards models of HIV-1 transmission included VL in all index partners and genital ulcers in all partners.
Results
In the index partners KIR2DS4*001, the only KIR2DS4 allele to encode a full length receptor, was associated with higher rates of HIV-1 transmission (OR = 2.40, 95% CI = 1.31-4.39, p = 0.003) by logistic regression. Survival analysis for KIR2DS4*001 demonstrated accelerated transmission of HIV-1 (RH = 1.72, p = 0.005). This allele in the seronegative partners was not associated with acquisition. The KIR2DS4*001 allele was also associated with a high VL (0.17 ± 0.08 log10, p < 0.05). No association was observed with its ligand, HLA-Cw*04, or with the HLA-Cw*04/KIR2DS4*001 combination. Previously reported findings on other KIR genes could not be confirmed.
Discussion
We observed an association of KIR2DS4*001 carriage by a seropositive partner with an increased hazard of HIV-1 transmission and with high VL. Whatever the significance of this KIR allele association in Zambian couples, it did not depend on epistatic interaction with HLA-Cw*04. The association will require confirmation in functional assays.
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Merino, A., Malhotra, R., Morton, M. et al. Killer immunoglobulin-like receptor genes and heterosexual HIV-1 transmission. Retrovirology 7, P105 (2010). https://doi.org/10.1186/1742-4690-7-S1-P105
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Keywords
- Viral Load
- High Viral Load
- Genital Ulcer
- Natural Killer Cell Function
- Serodiscordant Couple
